The 384-Well C-Trap Proteinase K Digestion and Desalting Kit from MtoZ Biolabs is an integrated, plate-based workflow that combines Proteinase K digestion with on-plate peptide desalting to support high-throughput LC-MS/MS sample preparation with minimal handling and consistent recovery across large sample sets.
Product Overview
Large-cohort proteomics projects place strict requirements on digestion consistency, cleanup efficiency, and plate-to-plate reproducibility. When sample numbers increase, the following pain points become more prominent:
1. Digestion Variability Across Large Plates
Small differences in mixing, incubation, and timing can lead to uneven peptide yield and reduced quantitative comparability.
2. Residual Matrix Interference
Salts, detergents, and buffer additives can increase background and suppress ionization, limiting identifications and sensitivity.
3. Handling-Driven Loss and Contamination Risk
Extra transfers and open processing steps increase adsorption loss and introduce variability, especially when processing hundreds of samples.
4. Throughput and Hands-On Time Pressure
Large studies benefit from a format that supports parallel processing without expanding manual workload.
Advantages
The MtoZ Biolabs 384-Well C-Trap Proteinase K Digestion and Desalting Kit offers the following advantages:
✅ 384-Well Throughput for Large Cohorts
Supports efficient parallel processing for screening, time-course, and multi-condition studies.
✅ Proteinase K Digestion for Broad Applicability
Robust proteolysis supports diverse protein compositions and complex sample matrices.
✅ Integrated Desalting for MS-Ready Peptides
Removes common interferents to deliver cleaner peptide preparations for LC-MS/MS.
✅ Fewer Transfers, More Consistent Recovery
Consolidated workflow reduces adsorption loss, contamination exposure, and operator variability.
✅ Plate-Wide Reproducibility for Batch Runs
Standardized workflow helps maintain consistent outputs across wells and plates.
Technical Support
1. Protocol Downloads
MtoZ Biolabs provides comprehensive experimental protocols and product manuals to help ensure smooth and reproducible workflows. For access to specific documents or detailed instructions, please contact our support team.
2. Customized Service Support
Our experienced scientists offer tailored technical assistance and customized solutions based on your specific research goals, helping you achieve optimal experimental outcomes.
3. FAQ and Expert Assistance
We provide responsive and professional technical support to address your questions efficiently. Our experts are ready to help you identify and resolve experimental challenges quickly and accurately.
