MtoZ Biolabs Acetonitrile with 0.1% Formic Acid, LC-MS Grade is a ready-to-use, high-purity organic mobile phase for LC/MS and UHPLC-UV. It provides consistent acidification and supports robust ESI response, helping improve peptide and protein peak shape and chromatographic resolution. This formulation is well suited for proteomics workflows, routine analyses, and method development where reproducibility and separation performance are critical.
Product Overview
In reversed-phase separations of complex peptides and proteins, even minor differences in mobile-phase composition and system cleanliness can be amplified into noticeable chromatographic and MS variability:
1. Small changes in organic content or acidity can shift selectivity and retention, increasing co-elution and compromising separation.
2. Secondary interactions with residual silanol groups or active sites in the LC system can cause peak tailing and broadening, reducing resolution.
3. Solvent impurities and trace metal ions may lead to ion suppression, metal-adduct formation, and ghost peaks, masking low-abundance signals.
4. On-bench preparation can introduce concentration error and environmental contamination, undermining retention time alignment and cross-batch comparability in large-cohort studies.
Advantages
✅ High-purity organic mobile phase for LC/MS and UHPLC-UV workflows.
✅ Ready-to-use premix to streamline daily operation.
✅ Ultra-low metal background to reduce adducts and carryover risk.
✅ Acidified formulation to support robust ESI performance.
✅ Chromatography-optimized for sharper peaks and better resolution.
Technical Support
1. Protocol Downloads
MtoZ Biolabs provides comprehensive experimental protocols and product manuals to help ensure smooth and reproducible workflows. For access to specific documents or detailed instructions, please contact our support team.
2. Customized Service Support
Our experienced scientists offer tailored technical assistance and customized solutions based on your specific research goals, helping you achieve optimal experimental outcomes.
3. FAQ and Expert Assistance
We provide responsive and professional technical support to address your questions efficiently. Our experts are ready to help you identify and resolve experimental challenges quickly and accurately.
