Ready-to-Use Coupling
The antibody is supplied pre-immobilized on the bead surface, avoiding a separate coupling step before immunoprecipitation.
IP-MS Validated Antibody-Coupled Magnetic Beads for IP, Co-IP, and IP-MS Workflows
Antibody-coupled magnetic beads combine an immobilized antibody with a magnetic support to provide a ready-to-use capture reagent for immunoprecipitation and related enrichment workflows. MtoZ Biolabs provides IP-MS validated magnetic bead products for common affinity tags, endogenous protein targets, immunoglobulin subclasses, immune-related targets, selected post-translational modifications, and other research applications.
The pre-coupled format removes the need for a separate antibody-to-bead coupling step and enables magnetic separation during washing and elution. Selected products are available in different bead sizes and antibody formats, supporting IP, Co-IP, and downstream LC-MS/MS studies according to product-specific application data.
Antibody-Coupled Magnetic Beads for Targeted Enrichment and Mass Spectrometry
MtoZ Biolabs offers pre-coupled magnetic bead products for tag-based capture, endogenous target enrichment, immune-related isolation, selected PTM enrichment, and downstream IP-MS workflows. The portfolio includes monoclonal, oligoclonal, VHH, and other antibody formats immobilized on magnetic supports. Product specifications, bead size, host, species reactivity, and recommended applications vary by product.
Magnetic Separation
Beads can be collected with a magnetic separator during incubation, washing, and elution steps without centrifugation-based pelleting.
Simplified Workflow Setup
A pre-coupled reagent format reduces the number of manual preparation steps required before target or complex enrichment.
IP-MS Compatibility
Selected products support immunoenrichment workflows that continue to LC-MS/MS for protein identification or interaction analysis.
Common Antibody-Coupled Magnetic Bead Categories
Tag-Specific Beads
DYKDDDDK, GFP/EGFP, HA, Myc, V5, mCherry, and additional tag-specific magnetic bead products.
Endogenous Target Beads
Pre-coupled beads for targets such as MDM2, MDM4, CBL, HERC5, MAGEA3, PML, TANK, and additional proteins.
Ubiquitin-Pathway Targets
Magnetic bead products for E3 ligases and related proteins, including CUL, DTX, NEDD4, RNF, TRIM, UBE3A, UBR7, UHRF2, WWP2, and more.
Immune & Immunoglobulin Capture
Products for pan MHC-I, HLA-C, human IgA, IgE, IgG subclasses, IgM, and related immune targets.
PTM-Specific Enrichment
Selected magnetic bead products for modification-class enrichment, including crotonyl lysine.
VHH & Specialized Capture
VHH-coupled magnetic beads and specialized products for GFP, HA, Myc, mCherry, TMEM192, and additional applications.
Featured IP-MS Validated Antibody-Coupled Magnetic Beads
Selected products from the MtoZ Biolabs magnetic bead portfolio. Bead size, antibody format, species reactivity, and supported applications vary by product.
HUMAN TMEM192
View product → IP-MS Validated Magnetic Beads-Conjugated Rabbit Anti-Human TMEM192 Antibody
IP · Co-IP · IP-MS compatible
Where Antibody-Coupled Magnetic Beads Are Used
Pre-coupled magnetic bead products support target capture, complex enrichment, immunoaffinity isolation, and sample preparation across multiple IP and mass spectrometry workflows.
Tagged Protein Immunoprecipitation
Enrich DYKDDDDK-, GFP/EGFP-, HA-, Myc-, V5-, mCherry-, and other tagged recombinant proteins for expression studies, complex capture, or downstream analysis.
Endogenous Protein & Complex Enrichment
Capture endogenous targets such as MDM2, MDM4, CBL, HERC5, PML, and related proteins together with associated complexes under suitable enrichment conditions.
Ubiquitin-Pathway Protein Studies
Support immunoenrichment of E3 ligases and related ubiquitin-pathway proteins, including CUL, DTX, NEDD4, RNF, TRIM, UBE3A, UBR7, UHRF2, and WWP2 family targets.
Immune & Immunoglobulin Capture
Isolate pan MHC-I, HLA-C, human immunoglobulin classes or subclasses, and other immune-related targets for biochemical or mass spectrometry-based analysis.
PTM Immunoaffinity Enrichment
Use modification-specific bead products to enrich selected PTM-bearing proteins or peptides before Western blotting or LC-MS/MS analysis.
Organelle & Specialized Capture
Apply specialized bead reagents such as TMEM192-coupled magnetic beads or VHH-coupled tag beads for compartment-focused or recombinant protein enrichment workflows.
From Magnetic Bead Enrichment to Mass Spectrometry Analysis
For projects extending beyond bead selection, MtoZ Biolabs provides downstream protein interaction and PTM mass spectrometry services for enriched targets, tagged proteins, native protein complexes, and modification-focused samples.
Frequently Asked Questions
Key considerations for selecting and using antibody-coupled magnetic beads in IP, Co-IP, and downstream mass spectrometry workflows.
Q1How should I select an antibody-coupled magnetic bead product?
Q2How do pre-coupled magnetic beads differ from using an unconjugated antibody with Protein A/G beads?
Q3Does bead size affect product selection?
Q4Can the same magnetic bead product be used for both IP and IP-MS?
Q5What controls are recommended for magnetic bead immunoprecipitation?
Q6Can MtoZ Biolabs support downstream IP-MS or Co-IP-MS after bead selection?
Find the Right Antibody for Your Research
Selecting the right antibody depends on target specificity, sample species, antibody format, host species, application, validation method, and downstream experimental goals. Use our product filter to quickly identify antibody products that match your experimental requirements.
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