MtoZ Biolabs’ Formic Acid, LC-MS Grade is designed for high-sensitivity LC-MS/UHPLC-MS analysis. As an ideal mobile-phase modifier, this product is manufactured under stringent purification and quality control to ensure extremely low metal-ion content and low background noise, helping improve ionization efficiency and analytical reproducibility in mass spectrometry.
Product Overview
In proteomics and peptide LC-MS workflows, the mobile-phase acidification system is often a critical variable that directly impacts peak shape, ionization stability, and data consistency. Common challenges include:
1. Peak Tailing and Band Broadening
Charged peptides can undergo secondary interactions with residual silanol groups or active sites in the LC system, resulting in poor peak shape and reduced resolution.
2. Metal Adducts and Interference Peaks
Trace levels of sodium and potassium can form adducts, creating extra peaks and compromising quantitative consistency.
3. Ion Suppression and Signal Instability
Impurities and non-volatile residues can exacerbate ion suppression, leading to unstable spray performance, response drift, and reduced reproducibility.
4. System Contamination and Higher Maintenance Burden
Lower-quality acids or residual contaminants can accumulate in the ion source and LC flow path, increasing cleaning frequency and shortening the lifetime of consumables.
Advantages
✅ Ultra-Low Background Interference
Minimizes baseline noise for accurate detection of trace-level analytes.
✅ Reduced Metal Adduct Formation
Sodium, potassium, and other metal ions are controlled at ppb levels to minimize interference peaks in MS spectra.
✅ Improved Peak Shape
Helps reduce peak tailing and enhances chromatographic resolution.
✅ High Volatility with No Residue
Evaporates cleanly to protect the ion source and chromatographic columns.
Technical Support
1. Protocol Downloads
MtoZ Biolabs provides comprehensive experimental protocols and product manuals to help ensure smooth and reproducible workflows. For access to specific documents or detailed instructions, please contact our support team.
2. Customized Service Support
Our experienced scientists offer tailored technical assistance and customized solutions based on your specific research goals, helping you achieve optimal experimental outcomes.
3. FAQ and Expert Assistance
We provide responsive and professional technical support to address your questions efficiently. Our experts are ready to help you identify and resolve experimental challenges quickly and accurately.
