IP-MS Validated Target Protein Antibodies for IP, Co-IP, and IP-MS Workflows

Target protein antibodies enable direct detection and enrichment of specific endogenous proteins and native protein complexes without introducing an affinity tag. MtoZ Biolabs provides IP-MS validated antibodies against a broad range of protein targets, supporting applications such as Western blotting, immunoprecipitation, co-immunoprecipitation, immunofluorescence, and protein interaction studies.

For studies extending from target enrichment to protein complex and interaction analysis, MtoZ Biolabs also provides downstream protein interaction mass spectrometry services, including IP-MS and Co-IP-MS, to support the identification and characterization of target-associated proteins and native protein complexes.

IP-MS Validated Target Protein Antibodies for IP, Co-IP, and IP-MS Workflows

Target Protein Antibodies for Detection, Enrichment, and Interaction Studies

MtoZ Biolabs offers IP-MS validated antibodies against a broad range of endogenous protein targets, with product options for detection, immunoprecipitation, co-immunoprecipitation, and downstream protein interaction mass spectrometry workflows. Our target protein antibody portfolio covers signaling molecules, receptors, transcriptional regulators, metabolic enzymes, cytoskeletal proteins, immune-related proteins, and more. Available formats include polyclonal, monoclonal, and recombinant monoclonal antibodies, with product options varying by target.

Target-Specific Recognition

Directly target endogenous proteins of interest without introducing an affinity tag, supporting native protein studies in biologically relevant systems.

Native Complex Enrichment

Support immunoprecipitation-based enrichment of endogenous proteins together with associated protein complexes under native or near-native conditions.

Workflow Flexibility

Compatible with multiple downstream applications, including target confirmation, co-immunoprecipitation, protein complex analysis, and interaction studies.

IP-MS Compatibility

Suitable for enrichment workflows that continue to LC-MS/MS, supporting interacting protein identification and protein complex characterization.

Common Target Protein Categories
Signaling Proteins
Kinases, phosphatases, adaptor proteins, and pathway regulators, including AKT, ERK/MAPK, STAT, mTOR, and more.
Receptors & Membrane Proteins
Receptor tyrosine kinases, immune checkpoints, and other membrane targets, including EGFR, HER2/ErbB2, PD-L1/CD274, ACE2, and more.
Nuclear & Regulatory Proteins
Transcription factors, tumor suppressors, nuclear receptors, and regulatory proteins, including p53, NF-κB, androgen receptor, and more.
Metabolic Enzymes
Metabolic enzymes and energy-regulating proteins, including ACLY, ALDH1A1, AMPK-related targets, and more.
Structural & Cellular Proteins
Cytoskeletal and cell-structure-associated proteins, including tubulin, ezrin, filamin, annexins, and more.
Additional Targets
Immune-related, disease-associated, organelle-associated, and other protein targets across a wide range of research areas.

Where Target Protein Antibodies Are Used

The MtoZ target protein antibody portfolio supports endogenous protein detection, immunoprecipitation, complex enrichment, and interaction analysis across major areas of molecular and cellular research.

Cancer Biology & Tumor Signaling

Study growth factor receptors, oncogenic kinases, tumor suppressors, immune checkpoints, and cancer-associated complexes, including targets such as EGFR, HER2/ErbB2, KRAS, BRAF, p53, and PD-L1/CD274.

Signal Transduction & Protein Regulation

Investigate endogenous receptors, kinases, transcriptional regulators, and pathway components involved in AKT, ERK/MAPK, JAK/STAT, NF-κB, mTOR, and related signaling networks.

Immunology & Inflammation

Analyze immune receptors, CD markers, Toll-like receptors, cytokine-associated proteins, checkpoint molecules, and inflammatory signaling complexes in immune-cell systems.

Apoptosis, Autophagy & Cell Cycle

Examine caspases, BCL-2 family proteins, PARP, cyclins, CDKs, LC3B, ATG proteins, SQSTM1/p62, and related regulators of cell death, proliferation, and proteostasis.

Metabolism & Mitochondrial Biology

Study metabolic enzymes and mitochondrial proteins involved in energy metabolism, lipid metabolism, redox regulation, and respiratory processes, including ACLY, ALDH, AMPK, ATP synthase, NDUF, and IDH-related targets.

Neuroscience & Neurodegeneration

Support endogenous protein studies involving neuronal markers, synaptic proteins, receptors, transporters, and neurodegeneration-associated targets such as GFAP, NeuN, MAP2, PSD95, Tau, APP, and NMDAR proteins.

From Target Protein Enrichment to Protein Interaction Mass Spectrometry Service

For projects extending beyond antibody selection, MtoZ Biolabs provides downstream and complementary protein interaction mass spectrometry services for endogenous target proteins, native protein complexes, and interaction systems requiring alternative enrichment strategies.

Frequently Asked Questions

Key considerations for target protein antibody selection, immunoprecipitation, and downstream mass spectrometry workflows.

Q1How should I select a target protein antibody for IP or Co-IP?

Q2Are the target protein antibodies in this category suitable for downstream mass spectrometry?

Q3Can the same antibody be used for both Western blotting and immunoprecipitation?

Q4What should I consider when working with low-abundance or membrane protein targets?

Q5How do I choose between monoclonal, recombinant monoclonal, and polyclonal antibodies?

Q6Can MtoZ Biolabs support downstream IP-MS or Co-IP-MS after antibody selection?

Find the Right Antibody for Your Research

Selecting the right antibody depends on target specificity, sample species, antibody format, host species, application, validation method, and downstream experimental goals. Use our product filter to quickly identify antibody products that match your experimental requirements.

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